Papers consist of personal correspondence, including substantial family correspondence, diaries, journals, engagement books, ledgers, menus, manuscript poems, galley proofs, lecture notes, scrapbooks, and photographs. It includes correspondence, 1874-1935; a diary of Drummond's trip to Great Britain, 1902; dinner menus, 1902-1903; engagement books, 1902-1906; galley proofs, 1905-1911; Journal of Impressions kept at Savanna la Mar, Jamaica, Windsor and Montreal, 1903-1911; lecture notes taken at McGill, 1878-1882; ledgers containing financial entries and patients' accounts during Drummond's practice in Knowlton and Montreal, 1885-1889; notebooks containing manuscripts poems, drafts and clippings, 1894-1909; scrapbooks related to literary topics, including clippings about Drummond's public readings, and book reviews, 1854-1907 and scrapbooks related to Drummond's dogs, 1890-1907. There are also some papers of Mrs. W.H. Drummond, including a typescript of her Life of W.H. Drummond; and diaries recording her trips to United States and Canada, 1892, 1903.

The Sir William Osler Collection, distinct from the Bibliotheca, is an extensive archival holding of Osler's correspondence (including eighteen hundred original letters), daybooks, accounts, engagement books, legal documents, book invoices, membership certificates, notebooks, lectures, addresses, newspaper clippings, photographs, books with manuscript additions, and miscellaneous loose items formerly inserted into individual books in his library. The collection also contains various family papers, including correspondence of Lady Grace Revere Osler and Edward Revere Osler.

Fonds contains five notebook kept by medical student S. J. Bennett while studying at McGill University's Faculty of Medicine. Each notebook is devoted to a subject of study, including one notebook each labelled "Medicine", "Bacteriology" and "Obstetrics" and two notebooks labelled "Pathology." The notes inside are dated between 1907 and 1908. The notes are organized in some cases by instructor and in some cases according to medical conditions.

The fonds consists of Robert Bell's student notebooks related to his medical studies in Surgery, Materia Medica, Practice of Medicine, Obstetrics, Physiology and Clinics at McGill University. The fonds also contains circular letters and medical advertisements. Inventory for acc.732 purchased from John Mappin in 1979 also included in fonds.

The fonds documents Purdy A. MacDonald's activities as a medical student at McGill University. The fonds contains student notebooks, loose notes and hand-outs.

The fonds contains Dr. Ormrod's note books while an undergraduate and medical student at McGill.

The fonds documents John Bell's activities related to his medical studies at McGill in Surgery, Materia Medica and the Institutes of Medicine, as well as his work as a private physician in Montreal. The fonds consists of notebooks, a photocopy of his MS McGill medical thesis, letters from his personal and professional life, one of his medical kits, receipts from merchants, various subscriptions, societies and clubs. The fonds also contains various reprints of Bell's articles, including the 1878 article, "Case of Diphtheria, Acute Laryngeal Symptoms", as well as the City of Montreal's "Mortality of Montreal" – a list of all deaths in Montreal in January 1878.

Fonds documents H.R. Clouston's medical activities and his association with McGill University. The fonds contains notes, reprints, photographs and newspapers clippings.

The fonds documents Dr. Hamish McIntosh's activities while studying medicine at McGill University from 1939 to 1943. The fonds contains his notes.